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目的探讨匹多莫德片联合伐昔洛韦片及阿达帕林凝胶治疗扁平疣患者的临床疗效。方法选取广州医科大学附属乐从医院皮肤科2016年5月至2017年5月收治的扁平疣患者80例为研究对象,根据随机数字表法将其分为试验组和对照组,每组40例。试验组患者采用匹多莫德片联合伐昔洛韦及外用阿达帕林凝胶进行治疗,对照组患者仅口服伐昔洛韦和外用阿达帕林凝胶,比较两组患者的疗效、不良反应发生情况及治疗后辅助性T细胞(CD4+)、抑制性T细胞(CD8+)、血清白细胞介素-2(IL-2)水平。结果试验组患者治疗的总有效率为90.0%,对照组为70.0%,差异有统计学意义(P<0.05);试验组患者不良反应发生率为10.0%,显著低于对照组的30.0%,差异有统计学意义(P<0.05);治疗后的试验组CD_4~+、CD_8~+、IL-2水平均明显高于对照组,差异均有统计学意义(均P<0.05)。结论匹多莫德片联合伐昔洛韦片及阿达帕林凝胶治疗扁平疣临床疗效明显,且不良反应发生率较低。
Objective To investigate the clinical efficacy of pidotimod tablets combined with valacyclovir tablets and adapalene gel in the treatment of patients with flat warts. Methods Eighty patients with flat warts who were admitted to Department of Dermatology, Lecong Hospital, Guangzhou Medical University from May 2016 to May 2017 were selected as study subjects. According to the random number table, they were divided into experimental group and control group, 40 cases in each group . Patients in the test group were treated with pidotimod tablets combined with valacyclovir and topical adapalene gel. In the control group, only valacyclovir and topical adapalene gel were administered. The curative effect and adverse reactions of the two groups were compared Occurrence and post-treatment of helper T cells (CD4 +), inhibitory T cells (CD8 +), serum interleukin-2 (IL-2) levels. Results The total effective rate was 90.0% in the trial group and 70.0% in the control group (P <0.05). The incidence of adverse reactions in the trial group was 10.0%, significantly lower than that in the control group (30.0%), (P <0.05). The levels of CD_4 ~ +, CD_8 ~ + and IL-2 in the experimental group after treatment were significantly higher than those in the control group (all P <0.05). Conclusion Pidotimod tablets combined with valacyclovir tablets and adapalene gel treatment of flat warts obvious clinical effect, and the incidence of adverse reactions is low.