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目的:探讨双歧三联活菌胶囊辅助治疗2型糖尿病(T2DM)的疗效和对患者血清炎症因子水平的影响.方法:102例T2DM患者按入院单双号分为观察组(n=53)和对照组(n=49).对照组予二甲双胍片0.5 g,po,tid;观察组在对照组基础上加用双歧三联活菌胶囊0.42 g,po,tid.8周为一疗程.治疗前后检测两组患者果糖胺、糖化血红蛋白和空腹血糖,血清TNF-α、脂联素的水平变化,并记录不良反应.结果:治疗后,两组患者果糖胺、糖化血红蛋白、空腹血糖、TNF-α水平均较治疗前下降,脂联素则较治疗前显著增高(P<0.05);且与对照组相比,对照组改善更为明显(P<0.05).两组均未见药品不良反应发生.结论:补充益生菌有助于T2DM患者血糖的控制,推测与降低炎症反应有关.“,”Objective:To investigate the clinical effect of probiotics adjuvant therapy and influence on inflammation in the patients with type 2 diabetes mellitus (T2DM). Methods:Totally 102 patients with T2DM were divided into probiotics group (n=53) and the control group (n=49)according to the odd-even admission number. The control group received metformin tablets of 0. 5g,po,tid,pro-bioties group received bifid triple viable capsules of 0. 42g,po,tid additionally, and the treatment course was 8 weeks. Before and after the treatment, the levels of fructosamine(FMN), fasting bloodglucose(FBG),HbA1c,and the serum levels of TNF-αand adiponectin were determined, and the adverse reactions were recorded. Results:After the treatment, the levels of FMN, FBG, HbA1c and TNF-αof the two groups were significantly decreased than before, and adiponectin was significantly increased than before (P<0. 05); com-pared with those of the control group, the indicators mentioned above were improved more greatly in probiotic group (P<0. 05). There were no obvious adverse reactions appeared in both groups. Conclusion:Probiotics is beneficial to glycemic control, and the mecha-nism is related to reducing inflammation.