STUDIES ON PATHOGENESIS OF WAARDENBURG SYNDROME TYPE ⅡAND TIETZ SYNDROME RESULTING FROM MITF GENE MU

• 作 者: ZHANG Hua LI Jiada LUO Hunjin
• 机 构: DepartmentofOtolaryngology,StateKeyLaboratoryofMedicalGenetics,DepartmentofOtolaryngology
• 出 处: 中华耳科学杂志：英文版
• 发表日期: 2013年2期
• 基金项目: We would like to thank Bondurand Nadege，Inoue Ken，Goding Colin R.，Jiri Vachtenheim (Laboratory Molecular and Cell Biology, University Hospital, Charles University, Bulovka, Czech Republic.) for genero

Microphthalmia-associated transcription factor (MITF) controls melanocyte survival and differentiation through directly regulating the expression of the tyrosinase (TYR) and tyrosinase-related proteins 1 and 2 (TYRP1 and TYRP2) genes. MITF mutations have