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目的探究降钙素对脓毒症的诊断价值。方法选取新疆生产建设兵团医院重症医学科2013年1月—2014年1月收治的96例危重症患者,其中52例为脓毒症患者,将其作为试验组,另外44例非脓毒症患者为对照组。患者入院后,在抗生素治疗前对所有患者进行静脉采血,共3份/人,测定并比较两组患者的降钙素、CRP及WBC。结果两组患者降钙素及CRP比较,差异有统计学意义(P<0.05);两组患者WBC比较,差异无统计学意义(P>0.05)。试验组中降钙素呈阳性48例,阳性率为92.3%;CRP呈阳性33例,阳性率为63.5%;WBC呈阳性22例,阳性率为42.3%。对照组中降钙素呈阳性25例,阳性率为56.8%;CRP呈阳性17例,阳性率为38.6%;WBC呈阳性15例,阳性率为34.1%。两组患者降钙素及CRP阳性率均高于对照组,差异有统计学意义(P<0.05)。结论降钙素检测对早期脓毒症患者的诊断具有较高敏感性,可将其作为一项临床诊断指标,为脓毒症患者提早用药提供可靠的依据。
Objective To investigate the diagnostic value of calcitonin in sepsis. Methods Ninety-six critically ill patients admitted to the Department of Critical Care Medicine of Xinjiang Production and Construction Corps Hospital from January 2013 to January 2014 were selected, of whom 52 were sepsis patients and were included in the test group. Another 44 non-sepsis patients For the control group. All patients received venous blood sampling before antibiotic treatment. A total of 3 patients were enrolled in this study. Calcitonin, CRP and WBC were measured and compared between the two groups. Results There was significant difference in calcitonin and CRP between the two groups (P <0.05). There was no significant difference in WBC between the two groups (P> 0.05). The experimental group calcitonin-positive in 48 cases, the positive rate was 92.3%; CRP-positive in 33 cases, the positive rate was 63.5%; WBC-positive in 22 cases, the positive rate was 42.3%. The control group calcitonin-positive 25 cases, the positive rate was 56.8%; CRP-positive in 17 cases, the positive rate was 38.6%; WBC-positive in 15 cases, the positive rate was 34.1%. The positive rates of calcitonin and CRP in both groups were significantly higher than those in the control group (P <0.05). Conclusions Calcitonin test is highly sensitive to the diagnosis of early sepsis patients and can be used as a clinical diagnostic indicator to provide a reliable basis for early treatment of patients with sepsis.