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目的谷氨酰转肽酶(GGT)、高尔基体糖蛋白73(GP73)、甲胎蛋白(AFP)联合检测在原发性肝癌(PHC)早期诊断中的临床价值。方法选取原发性肝癌(PHC)组研究对象65例,肝炎后肝硬化(LC)组研究对象62例,健康对照(HV)组研究对象60例。分别对三组测试对象进行GGT、GP73、AFP水平检测并分析。结果 PHC组与LC组、HV组间三指标表达水平明显升高,差异均有统计学意义(P<0.05);三指标联合检测对PHC患者的阳性检出率达到85.6%,高于各指标单独检测。结论 GGT、GP73和AFP在PHC患者血清中存在高表达,三指标联合检测可明显提高对原发性肝癌的检出率,有较好的应用价值。
Objective To investigate the clinical value of combined detection of GGT, GP73 and AFP in the early diagnosis of primary liver cancer (PHC). Methods Sixty-five subjects from the primary liver cancer (PHC) group, 62 from the post-hepatitis cirrhosis (LC) group and 60 from the healthy control (HV) group were enrolled. Three groups of test subjects were respectively tested for GGT, GP73 and AFP levels and analyzed. Results The expression levels of three indicators in PHC group, LC group and HV group were significantly higher than those in PHC group (P <0.05), and the positive rate of PHC group was 85.6% Test alone. Conclusions GGT, GP73 and AFP are highly expressed in the serum of patients with PHC. Combined detection of three indicators can significantly improve the detection rate of primary liver cancer, which has a good value.