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目的:评价国产雷帕霉素药物涂层支架(爱克塞尔支架EXCEL,山东吉威公司)治疗冠心病合并糖尿病长期临床疗效。方法:冠心病合并糖尿病患者32例行经皮冠状动脉介入治疗,置入EXCEL支架51个,病变长度12～41mm,平均(21.2±4.3)mm,术前病变狭窄程度(82.9%±8.5%);血管直径(3.00±0.75)mm。结果:32例均手术成功,术后造影病变残余狭窄(4.8%±2.3%),支架覆盖病变完全,支架近、远端无夹层,血流TIMI3级。所有患者住院期间均无MACE发生。长期随访无死亡病例发生,2例再次发作心绞痛,其中1例再次接受PCI治疗。28例于术后6～9个月复查冠状动脉造影,2例发生支架内再狭窄,占7.14%。结论:国产EXCEL雷帕霉素药物涂层支架治疗冠心病合并糖尿病是安全有效的方法。
OBJECTIVE: To evaluate the long-term clinical efficacy of domestic rapamycin-eluting stent (Exxel stent EXCEL, Shandong Jiwei Company) in the treatment of coronary heart disease complicated with diabetes. Methods: Twenty-two patients with coronary heart disease and diabetes mellitus underwent percutaneous coronary intervention with 51 EXCEL stents. The length of the lesions was 12 to 41 mm (mean 21.2 ± 4.3 mm, preoperative lesion stenosis 82.9% ± 8.5% ; Vascular diameter (3.00 ± 0.75) mm. Results: All the 32 cases were operated successfully. The residual stenosis of postoperative angiography was (4.8% ± 2.3%). The stent covered the lesion completely. There was no dissection and distal TIMI3 grade in the stent. None of the patients had MACE during hospitalization. No long-term follow-up deaths occurred, 2 patients had recurrent angina pectoris, of which 1 again received PCI. Coronary angiography was performed in 28 cases 6 to 9 months after surgery and in-stent restenosis in 2 cases (7.14%). Conclusion: The domestic EXCEL rapamycin coated stent is safe and effective in the treatment of coronary heart disease complicated with diabetes mellitus.