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目的:探讨高氧恢复对低氧训练红细胞参数的影响及其机制。方法:雄性SD大鼠53只,随机分为常氧安静组、常氧训练组、低氧安静组、低氧训练组、常氧训练高氧恢复组、低氧训练高氧恢复组6组。接受不同的处理,4周后测定各组大鼠的Hb、RBC和HCT。结果:常氧运动高氧恢复组血红蛋白的值为各组中最低;低氧运动高氧恢复组血红蛋白值,只与低氧安静组有显著性差异(P<0.05),与其它各组没有明显差异(P>0.05)。各组大鼠的红细胞总数的变化与血红蛋白的变化基本呈现同一规律。而各组大鼠的红细胞压积以低氧安静组最高、常氧安静组最低,但各组间没有显著性差异(P>0.05)。结论:低氧训练后进行高氧恢复在一定程度上降低了SD大鼠的红细胞参数,其机制可能跟高血氧分压抑制机体EPO的分泌等有关。
Objective: To investigate the effect and mechanism of hyperoxia recovery on hypoxic training erythrocyte parameters. Methods: Fifty-three male Sprague-Dawley rats were randomly divided into 6 groups: normoxia group, normoxia group, hypoxia group, hypoxia group, normoxia group and hypoxia group. After receiving different treatment, rats in each group were assayed for Hb, RBC and HCT after 4 weeks. Results: The values of hemoglobin in normoxia hyperoxia recovery group were the lowest among all groups. The hemoglobin values in hypoxic exercise hyperoxia recovery group were significantly different from those in hypoxia quiescence group (P <0.05), but not in other groups Difference (P> 0.05). The changes of the total number of red blood cells of rats in each group showed the same pattern with that of hemoglobin. The hematocrit of the rats in each group was the highest in the hypoxia-quiet group, the lowest in the normoxia-quiet group, but there was no significant difference among the groups (P> 0.05). CONCLUSION: Hypoxic training after hypoxia can reduce erythrocyte parameters of SD rats to a certain extent. The mechanism may be related to the inhibition of hyperoxia partial pressure on the secretion of EPO.