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目的分析9例微囊型脑膜瘤(MM)临床病理特征。方法回顾性分析9例MM患者的临床资料及病理形态学特征,并复习相关文献。结果 9例患者病变均位于大脑半球,临床表现以头痛、头晕为主。镜下见拉长的细胞质突起形成多个囊腔,均未见经典型脑膜瘤的漩涡状结构,未见高级别脑膜瘤形态。免疫组化为波形蛋白强阳性表达,上皮膜抗原、孕激素受体局灶阳性表达,Ki67增殖指数为1%-5%。结论 MM是一种少见的独特脑膜瘤亚型,具有特殊的组织学特点,容易误诊,大多预后良好,极少数病例可复发或恶性转化。
Objective To analyze the clinicopathological features of 9 patients with microcapsular meningioma (MM). Methods Retrospective analysis of 9 cases of MM patients with clinical data and pathological features, and review the relevant literature. Results All the 9 patients were located in the cerebral hemispheres. The main clinical manifestations were headache and dizziness. Microscopic see elongated elongated cytoplasm formation of multiple cysts, were not seen classic swollen meningioma structure, no high-grade meningioma morphology. Immunohistochemistry strongly expressed vimentin, epithelial membrane antigen, progesterone receptor focal expression, Ki67 proliferation index of 1% -5%. Conclusion MM is a rare and unique subtype of meningiomas with special histological features. It is easily misdiagnosed, most of the patients have a good prognosis. In a very small number of cases, recurrent or malignant transformation is possible.