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目的：探讨位于颅底中线和／或近中线区的肿瘤用X-刀立体定向放射外科方法治疗的效果。方法：采用X-刀立体定向放射外科方法，对6例肿瘤7个病灶进行了治疗。该7个病灶皆为颅底上区和颅底骨本身的肿瘤，包括脑膜瘤1例，垂体瘤2例，黑色素瘤1例，转移癌3个病灶。为减轻X-刀术后脑水肿等并发症，采用了分次分割，多靶点的放射治疗方法。结果：所有患者随访6～16月，除1例脑膜瘤外，余5例6个病灶或消失或不同程度的缩小。结论：X-刀治疗颅底肿瘤，对于年老体弱合并心肺疾病而不易手术的患者不失为一种好方法。
Objective: To investigate the effect of X-knife stereotactic radiosurgery on tumors located in the midline and / or near-midline skull base. Methods: Seven lesions of 6 tumors were treated with X-knife stereotactic radiosurgery. The 7 lesions were all tumors of the skull base area and the skull base itself, including 1 meningioma, 2 pituitary adenoma, 1 melanoma and 3 metastatic carcinomas. In order to alleviate the complications such as cerebral edema after X-knife operation, the method of fractionated and multi-target radiotherapy was adopted. Results: All the patients were followed up for 6 to 16 months. Except for 1 case of meningioma, the remaining 5 cases or 6 lesions disappeared or reduced to some extent. Conclusion: X-knife treatment of skull base tumors, for frail elderly patients with cardiopulmonary disease is not easy to surgery patients is a good way.