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Somatic development and rate of complications were studied prospectively in 25 patients receiving long-term parenteral nutrition in 14 German hospitals. For 12 months (3-20) the following data were collected at the beginning, in the middle, and at the end of the study: diagnosis, age at beginning of parenteral nutrition, complications, height, weight, growth velocity and body mass index (BMI), as well as transaminases and bilirubin levels. Catheter-associ-ated complications were observed once per year and patient (mechanical 0.46, septic 0.39, and thrombotic 0.15). At the beginning (and at the end)-of the study period 10 patients (12) had normal liver function (group N), 8 patients (6) showed hepatopathy (group H), and 6 (3) patients exhibited hepatopathy with hyperbilirubinemia (group HB). Four patients were weaned from parenteral nutrition. The median (25th/75th percentile) of SDS for height and BMI at beginning in group HB were -5.3 (-8.5/-4.3) and -2.9 (-3.6/0.1), in group H -2.4 (-4.5/-0.7) and 0.1 (2.3/0.5), and in group N -2.15 (-3.2/-2.0) and -0.9 (-1.8/0.4). The SDS for height velocity were -0.7 (-4.0/0.4), -2.35 (-3.6/-1.0), and -1.1 (-2.9/2.8) in groups HB, H, and N, respectively. Only in group HB with a high percentage of parenterally provided calories did SDS for height (-3.6; -4.5/-2.2) and BMI (0.5; -1.5/1.6) improve significantly (p 0.05). Rates of complications are comparable to published results. The somatic development of our patients is unsatisfying, likely due to inadequate nutrition. Parenteral nutrition only provides certain amounts of the total requirements and it might be possible that oral intake of nutrients or their intestinal absorption is lower than assumed. u001a
Somatic development and rate of complications were studied prospectively in 25 patients receiving long-term parenteral nutrition in 14 German hospitals. For 12 months (3-20) the following data were collected at the beginning, in the middle, and at the end of the study: diagnosis, age at beginning of parenteral nutrition, complications, height, weight, growth velocity and body mass index (BMI), as well as transaminases and bilirubin levels. Catheter-associ-ated complications were observed once per year and patient 0.46, septic 0.39, and thrombotic 0.15) At the beginning (and at the end) -of the study period 10 patients (12) had normal liver function (group N), 8 patients (6) showed hepatopathy (group H), The median (25th / 75th percentile) of SDS for height and BMI at beginning in group HB were -5.3 (-8.5 / -), and 6 (3) patients exhibited hepatopathy with hyperbilirubinemia (group HB) 4.3) and -2.9 (-3.6 / 0.1), in group H -2.4 ( -4.5 / -0.7) and 0.1 (2.3 / 0.5), and in group N -2.15 (-3.2 / -2.0) and -0.9 (-1.8 / 0.4). The SDS for high velocity were -0.7 (-4.0 / 0.4 ), -2.35 (-3.6 / -1.0), and -1.1 (-2.9 / 2.8) in groups HB, H, and N, respectively. Only in group HB with a high percentage of parenterally provided calories did SDS for height (- 3.6; -4.5 / -2.2) and BMI (0.5; -1.5 / 1.6) improve significantly (p 0.05). The somatic development of our patient is unsatisfying, likely due to inadequate nutrition. Parenteral nutrition only provide certain amounts of the total requirements and it might be that oral intake of nutrients or their intestinal absorption is lower than assumed.