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目的：探讨抗结核化疗伴类赫反应的发生机理及糖皮质激素的治疗作用。方法：回顾性分析肺结核患者化疗过程中出现类赫氏反应３９例中，１２例辅助给予强的松每天３０ｍｇ，２７例辅助给消炎痛每天５０ｍｇ，比较两组发热消退天数。结果：治疗组发热消退４．２０±４．４０ｄ，对照组发热消退１３．１５±１４．００ｄ。两组差异有显著性（Ｐ＜０．０５）。结论：采用强的松辅助抗痨治疗，能迅速降低全身毒血症状，刺激食欲，增加体重，疗程以３～４周为安全、有效。
Objective: To investigate the mechanism of anti-tuberculosis chemotherapy with Hegher reaction and the therapeutic effect of glucocorticoids. Methods: Thirty-nine cases of Hirschsprung’s reaction during chemotherapy were retrospectively analyzed. Twelve of them were given prednisone 30mg daily and 27 patients were given adjuvant indomethacin 50mg daily. The days of fever subsided in two groups were compared. Results: The treatment group subsided fever 4.20 ± 4.40d, the control group subsided fever 13.15 ± 14.00d. The difference between the two groups was significant (P <0.05). Conclusion: The prednisone-assisted anti-tuberculosis treatment can rapidly reduce systemic symptoms of poisoning, stimulate appetite and increase body weight. The course of treatment is 3-4 weeks safe and effective.