论文部分内容阅读
鸦片肽类参与ACTH分泌的调节,可能起神经递质或神经调节剂的作用,特异性鸦片拮抗剂纳络酮能影响其效应。最近,Tolis等报告输注低剂量纳络酮(0.8mg/h)可降低原发性肾上腺功能不全与Nelson综合征病人已升高的血浆ACTH浓度。他们的结论是,鸦片拮抗剂对于ACTH过度分泌可能有治疗价值;另方面,曾有人证明高剂量纳络酮能增加正常ACTH和皮质醇浓度,还可增加原发性肾上腺功能不全患者的血浆ACTH含量。为了进一步阐明与剂量相关的纳络酮对ACTH分
Opioid peptides involved in the regulation of ACTH secretion may play a neurotransmitter or neuromodulator role, the specific opioid antagonist naloxone can affect its effect. Recently, Tolis et al reported that infusion of low-dose naloxone (0.8 mg / h) reduced elevated plasma ACTH levels in patients with primary adrenal insufficiency and Nelson syndrome. They conclude that opiate antagonists may have therapeutic value for the hypersecretion of ACTH; on the other hand, it has been demonstrated that high doses of naloxone increase normal ACTH and cortisol concentrations and also increase plasma ACTH in patients with primary adrenal insufficiency content. In order to further elucidate dose-related naloxone scores on ACTH