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目的:探究埃索美拉唑与奥美拉唑治疗反流性食管炎的临床药效比较。方法:140例反流性食管炎患者随机分为观察组和对照组,分别给予埃索美拉唑和奥美拉唑,治疗8周后统计两组临床症状积分,胃镜下粘膜愈合情况及不良反应。结果:观察组临床症状积分低于对照组,两组胃镜下粘膜愈合分别为62和56例,显效为6和7例,愈合率为88.6%和80.0%,总有效率为97.1%和90.0%,不良反应发生率为2.9%和10.0%,(p<0.05)。结论:埃索美拉唑治疗反流性食管炎临床药效优于奥美拉唑,值得临床应用。
Objective: To investigate the clinical efficacy of esomeprazole and omeprazole in the treatment of reflux esophagitis. Methods: A total of 140 patients with reflux esophagitis were randomly divided into observation group and control group, and were given esomeprazole and omeprazole respectively. After 8 weeks of treatment, the clinical symptom scores, mucosal healing under gastroscopy, reaction. Results: The score of clinical symptom in the observation group was lower than that in the control group. The mucosal healing under the gastroscope was 62 and 56 respectively in two groups. The effective rates were 88.6% and 80.0%, the total effective rates were 97.1% and 90.0% The incidence of adverse reactions was 2.9% and 10.0%, respectively (p <0.05). Conclusion: The clinical efficacy of esomeprazole in the treatment of reflux esophagitis is better than omeprazole, which is worthy of clinical application.