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目的:探讨磷酯酶CE1(PLCE1)在肺鳞状细胞癌组织中的表达及意义。方法:采用免疫组化SP法检测48例肺鳞状细胞癌组织和48例正常肺组织中PLCE1的表达,分析其表达与肺鳞状细胞癌组织临床病理特征的关系。结果:肺鳞状细胞癌组织中PLCE1的阳性表达率为81.3%(39/48),高于正常肺组织的12.5%(6/48)(χ2=26.561,P<0.001)。PLCE1的表达与肺鳞状细胞癌淋巴结转移和肿瘤分期有关(χ2=6.274和4.255,P<0.05),而与性别、年龄、肿瘤分化程度无关(P>0.05)。结论:PLCE1可能与肺鳞状细胞癌的发生、发展相关,PLCE1蛋白检测可能有助于肺鳞状细胞癌的预后判断。
Objective: To investigate the expression of phospholipase CE1 (PLCE1) in lung squamous cell carcinoma and its significance. Methods: The expression of PLCE1 in 48 cases of lung squamous cell carcinoma and 48 cases of normal lung tissues was detected by immunohistochemical SP method. The relationship between the expression of PLCE1 and the clinicopathological features of squamous cell lung cancer was analyzed. Results: The positive expression rate of PLCE1 in lung squamous cell carcinoma was 81.3% (39/48), which was higher than that in normal lung tissues (12.5% (6/48)) (χ2 = 26.561, P <0.001). The expression of PLCE1 was correlated with lymph node metastasis and tumor staging of lung squamous cell carcinoma (χ2 = 6.274 and 4.255, P <0.05), but not with sex, age and tumor differentiation (P> 0.05). Conclusion: PLCE1 may be associated with the occurrence and development of lung squamous cell carcinoma. The detection of PLCE1 protein may contribute to the prognosis of lung squamous cell carcinoma.