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近二十年来,随着放疗设备和技术的发展及综合治疗的应用,头颈肿瘤治愈率明显提高,病人生存期延长,同时头颈照射的远期效应更多地表现出来,尤其内分泌功能的损伤,严重地影响了患者的生存质量,因而日益引起人们的重视。本文仅就头部照射对下丘脑一垂体轴功能的影响做一介绍。一、下丘脑-垂体轴(HPA)的敏感性长期以来,人们一直认为脑垂体对射线非常抗拒。在使用垂体照射法治疗月经失调,晚期乳癌等非垂体性疾病时发现要破坏
In the past two decades, with the development of radiotherapy equipment and technology and the application of comprehensive treatment, the cure rate of head and neck cancers has been significantly improved, the survival of patients has been prolonged, and the long-term effects of head and neck irradiation have been more manifested, especially the damage of endocrine function. Seriously affect the quality of life of patients, and thus increasingly attract people’s attention. This article only introduces the effect of head irradiation on the hypothalamus-pituitary axis function. First, the sensitivity of the hypothalamic-pituitary axis (HPA) has long been thought that the pituitary gland is very resistant to radiation. Pituitary irradiation was used to treat menstrual disorders, advanced breast cancer and other non-pituitary diseases found to be destroyed