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以生物相容性好且可生物降解的海藻酸钠(Sodium Alginate,Alg)、几丁聚糖(Chitosan,Chi)为壁材,采用静电液滴装置制备了球形度好、表面光洁、分散性好、平均粒径为210μm的海藻酸钙(Calcium Alginate,Ca-Alg)胶珠,并以卡培他滨(CAP)为模型药物,采用一步法和两步法制备了栓塞型载CAP Ca-Alg/Chi微胶囊,并考察了CAP浓度对微胶囊载药量和药物释放的影响。结果表明:随着CAP浓度的增大,载药量增大,包封率却随之减小;微胶囊在0.5 h内的累积释放量不到20%,无突释效应;微胶囊有一定的缓释性能,有望成为一种栓塞型抗肿瘤药物新剂型。
With good biocompatibility and biodegradability of sodium alginate (Alg) and chitosan (Chi) as the wall material, the spheres with good sphericity, smooth surface and dispersibility (Ca-Alg) beads with an average particle size of 210μm, and CAP-containing CAP Ca-Alg beads were prepared by one-step and two-step methods. Alg / Chi microcapsules, and investigated the concentration of CAP on the microcapsule drug loading and drug release. The results showed that with the increase of CAP concentration, the drug loading increased and the entrapment efficiency decreased. The cumulative release of microcapsules within 0.5 h was less than 20% Sustained-release properties, is expected to become a new type of embolic antitumor drugs.