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目的:通过对壮骨关节丸引起肝损害病例的分析,为合理用药提供参考。方法:总结近7年来本院发生的壮骨关节丸引起肝损害的病例共12例,分析肝损害的发生情况、发病时间、临床特点及消耗费用。结果:1996年以前肝损害病例多,平均服药48天后出现症状,ALT为45～1065U/L,T-BIL为21.3～376μmol/L,平均住院39.44天,平均消耗5605.36元。结论:药品管理部门应加强对该药的说明书和药品广告的管理,服药的患者应定期监测肝功能。
Objective: To analyze the cases of liver damage caused by Zhuanggu Joint Pills and provide reference for rational drug use. METHODS: A total of 12 cases of liver injury caused by Zhuanggu Pills in this hospital were reviewed in the past 7 years. The incidence, onset time, clinical features, and cost of liver damage were analyzed. Results: There were many cases of liver damage before 1996. Symptoms appeared after 48 days of average medication. ALT was 45 to 1065 U/L, and T-BIL was 21.3 to 376 μmol/L. The average length of hospitalization was 39.44 days and the average consumption was 5605.36. Conclusion: The drug administration department should strengthen the management of the drug’s instructions and drug advertisements, and patients taking drugs should regularly monitor liver function.