论文部分内容阅读
目的:探讨Calcyclin在良性前列腺增生、前列腺上皮内瘤变和前列腺癌诊断中的意义。方法:收集90例前列腺不同病变的常规石蜡标本,HE光镜下观察,应用免疫组织化学方法,观察Calcyclin的表达并分析各组间关系。结果:良性前列腺增生28/30例为阳性或强阳性连续性表达,前列腺上皮内瘤变24/28例为弱阳性非连续性表达,前列腺癌30/32例为阴性表达。3组间差异均有统计学意义(χ2=27.36、23.33、36.23,P<0.05)。结论:Calcyclin是前列腺癌敏感而特异性的标记物,有助于前列腺癌的诊断。
Objective: To investigate the significance of Calcyclin in the diagnosis of benign prostatic hyperplasia, prostatic intraepithelial neoplasia and prostate cancer. Methods: Totally 90 paraffin specimens of different prostatic diseases were collected and observed under HE light microscope. The expression of Calcyclin was observed by immunohistochemical method and the relationship between the groups was analyzed. Results: 28/30 cases of benign prostatic hyperplasia were positive or strongly positive continuous expression, 24/28 cases of prostatic intraepithelial neoplasia were weakly positive non-continuous expression, 30/32 cases of prostate cancer was negative expression. The differences among the three groups were statistically significant (χ2 = 27.36, 23.33, 36.23, P <0.05). CONCLUSIONS: Calcyclin is a sensitive and specific marker of prostate cancer and contributes to the diagnosis of prostate cancer.