【摘 要】
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Carbon nanomaterials offer excellent prospects as therapeutic agents,and among them,graphene quantum dots (GQDs) have gained considerable interest thanks to the
【机 构】
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Centre of Excellence for Nanostructured Materials (CENMAT),INSTM,Department of Chemical and Pharmace
论文部分内容阅读
Carbon nanomaterials offer excellent prospects as therapeutic agents,and among them,graphene quantum dots (GQDs) have gained considerable interest thanks to their aqueous solubilify and intrinsic fluorescence,which enable their possible use in therancotic approaches,if their biccompatibility end favorable pharmacolinetic are confirmed.We prepared ultra-small GQDs using an alternative,reproducible,top-down synthesis starting from graphene oxide with a nearly 100％ conversion.The materials were tested to assess their safety,demonstrating good biocompatibility and ability in passing the uitrafiltration barrier using anin vitro model.This leads to renal excretion without affecting the kidneys.Moreover,we studied the GQDs in vivo biodistribution confirming their efficient renal clearance,and we demonstrated that the internalization mechanism into podocytes is caveolae-mediated.Therefore,considering the reported characteristics,it appears possible to vehiculate compounds to kidneys by means of GQDs,overcoming problems related to lysosomal degradation.
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