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以豚鼠为对象,向其胆囊内植入人胆固醇及胆色素结石各一块,用低、中、高三种剂量及UDCA治疗一月。结果显示:1.中剂量金石散和UDCA均具有明显溶解胆固醇结石的作用,两者效应相仿,比中剂量大一倍的高剂量溶石效应稍有增加,而低剂量则不显溶石作用。2.对胆色素结石三种剂量金石散均具明显溶石作用,UDCA则无。3.低剂量金石散和UDCA显示具有明显利胆作用。4.动物喂金石散后,胆汁中胆汁酸含量明显升高而胆红素含量显著降低,这可能与金石散的溶石机制有关。
Guinea pigs as the object, the gallbladder implantation of human cholesterol and bile pigment stones each one, with low, medium and high doses of three and UDCA treatment in January. The result shows: 1. The middle dose of Jinshi Powder and UDCA both have the effect of dissolving cholesterol stones obviously. The effect of both is similar, the effect of high dose of limestone is slightly higher than that of medium dose, but the effect of low dose is not obvious. 2. On the three doses of lithotrophic stone Jinshi powder are obvious limestone effect, UDCA no. 3. Low-dose jinshisan and UDCA showed significant choleretic effect. 4. Feeding Jinshi powder, the bile acid content was significantly increased bilirubin and bilirubin content significantly reduced, which may be related to the dissolution of Jinshi scattered stone mechanism.