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通过检测链脲佐菌素（ＳＴＺ）诱导的迟发性糖尿病大鼠外周血Ｔ细胞亚群及胰岛细胞自身抗体（ＩＣＡｓ）的水平，了解Ｔ细胞亚群与ＩＣＡｓ在糖尿病外周血中变化规律与发病机制的关系及临床意义。结果显示：大鼠在糖尿病发病后１～５周内，外周血ＣＤ＋２与对照组比较无显著性改变，ＣＤ＋４明显升高，ＣＤ＋８显著降低，ＣＤ＋４／ＣＤ＋８比值升高；ＩＣＡｓ阳性率在发病后第１～２周内为４５４５％，第３周为２７２７％，第５周为２０％，于第５周以后均转为阴性。从而进一步证实了胰岛素依赖型糖尿病（ＩＤＤＭ）是细胞免疫介导的，ＣＤ＋４Ｔ细胞是发病的基础。ＣＤ４、ＣＤ８与ＩＣＡｓ是用于临床诊断ＩＤＤＭ的指标。为临床诊断或胰腺移植诊治提供捕捉阳性率最高的病程阶段
By detecting the levels of peripheral blood T cell subsets and islet cells autoantibodies (ICAs) in streptozotocin (STZ) -induced delayed-diabetes rats, we know the changes of T cell subsets and ICAs in peripheral blood of diabetic patients and Pathogenesis and its clinical significance. The results showed that within 1 to 5 weeks after the onset of diabetes, there was no significant change in peripheral blood CD + 2 compared with the control group, CD + 4 significantly increased, CD 8 decreased and the ratio of CD 4 / CD 8 increased. 45 45% within 1 ~ 2 weeks, 27 27% in the third week, and 20% in the fifth week, all turned negative after the fifth week. Further confirming that insulin-dependent diabetes mellitus (IDDM) is mediated by cellular immunity, CD + 4T cells are the basis of the disease. CD4, CD8 and ICAs are indicators of clinical diagnosis of IDDM. Provide the highest positive rate of capture stage for clinical diagnosis or pancreatectomy