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目的:探讨血必净注射液联合前列腺素E1(PGE1)注射液对实验性急性肺间质纤维化大鼠的肿瘤坏死因子-α(TNF-α)的影响。方法:采用一次性气管内注射博来霉素(BLM)的方法复制大鼠肺间质纤维化模型,将大鼠随机分为6组,待处死后,行支气管肺泡灌洗并收集灌洗液(BALF)用ELISA方法测定TNF-α水平。结果:血必净联合PGE1明显抑制TNF-α的表达,尤其第7天时与各组比较(P<0.05或0.01)。结论:血必净联合PGE1联合应用能有效抑制实验性肺纤维化大鼠TNF-α的表达。
Objective: To investigate the effect of Xuebijing injection combined with prostaglandin E1 (PGE1) injection on tumor necrosis factor-α (TNF-α) in experimental acute pulmonary fibrosis rats. METHODS: Rat pulmonary interstitial fibrosis model was induced by one-time intratracheal injection of bleomycin (BLM). Rats were randomly divided into 6 groups. After euthanasia, bronchoalveolar lavage was performed and lavage fluid was collected. (BALF) TNF-alpha levels were determined by ELISA. Results: The combination of Xuebijing and PGE1 significantly inhibited the expression of TNF-α, especially on the 7th day (P<0.05 or 0.01). Conclusion: Combined use of Xuebijing with PGE1 can effectively inhibit the expression of TNF-α in experimental pulmonary fibrosis rats.