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目的 :探讨格列本脲联用二甲双胍治疗 2型糖尿病的临床疗效及安全性。方法 :本院门诊病人 3 6例 ,均经饮食及运动疗法治疗无效的 2型糖尿病病人 ,入选前未服用任何降糖药物 ,并除外重症糖尿病 (包括急性并发症 )、肝肾功能明显异常、体重明显下降 ( >10 % )等。起始剂量 :格列本脲 2 5mg ,早餐前半小时服一次 ,二甲双胍 0 2 5 ,早晚餐时或餐后各服一次。治疗前及治疗后每两周检测一次空腹血糖及餐后 2h血糖 ,总疗程 13周。结果 :格列本脲、二甲双胍二联疗法治疗 13周后 ,空腹血糖下降3 6mmol/L ,餐后 2h血糖下降 4 3mmol/L ,血甘油三酯下降 0 7mmol/L ,无明显不良反应 ,顺从性良好。结论 :初诊 2型糖尿病经饮食及运动疗法治疗无效时采用格列本脲 +二甲双胍联合治疗 ,效果肯定 ,顺从性好。
Objective: To investigate the clinical efficacy and safety of glyburide in combination with metformin in the treatment of type 2 diabetes mellitus. Methods: Thirty-six outpatients in our hospital were treated with diet and exercise therapy. All patients with type 2 diabetes who did not receive any hypoglycemic drugs before and without severe diabetes mellitus (including acute complications), liver and kidney dysfunction, Significant weight loss (> 10%) and so on. Starting dose: glyburide 25mg, half an hour before breakfast once, metformin 025, breakfast and dinner or after meals, each time. Fasting blood glucose and 2-hour postprandial blood glucose were measured every two weeks before and after treatment. The total duration of treatment was 13 weeks. Results: Glibenclamide, metformin combined therapy for 13 weeks, fasting blood glucose decreased 36mmol / L, 2h postprandial blood glucose decreased 43mmol / L, triglyceride decreased 07mmol / L, no significant adverse reactions, compliance Good sex. Conclusions: The treatment of newly diagnosed type 2 diabetes mellitus with glyburide + metformin is ineffective when treated by diet and exercise therapy. The effect is good and the compliance is good.