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目的观察硫酸吗啡缓释片联合放疗治疗骨转移中重度癌痛的镇痛效果。方法选择2009年4月—2013年5月我院收治的骨转移癌患者70例,将其随机分为A组和B组,各35例。A组行口服硫酸吗啡缓释片联合放疗,B组行单纯口服硫酸吗啡缓释片。比较两组患者疼痛缓解率,并观察不良反应发生率。结果 A组患者总缓解率为91%(32/35),高于B组的80%(28/35)(P<0.05);A组患者恶心、呕吐、便秘、嗜睡等不良反应发生率低于B组(P<0.05)。结论硫酸吗啡缓释片联合放疗治疗中重度骨转移癌痛,镇痛效果迅速且较持久,提高了患者生活质量。
Objective To observe the analgesic effect of morphine sulfate sustained-release tablets combined with radiotherapy in the treatment of severe cancer pain in bone metastases. Methods From April 2009 to May 2013, 70 patients with bone metastases admitted to our hospital were randomly divided into A group and B group, 35 cases in each group. A group of oral morphine sulfate sustained-release tablets combined with radiotherapy, B group of simple oral morphine sulfate sustained-release tablets. The pain relief rate was compared between the two groups and the incidence of adverse reactions was observed. Results The total remission rate in group A was 91% (32/35), which was higher than that in group B (80/80) (P <0.05). The incidence of adverse reactions such as nausea, vomiting, constipation and drowsiness in group A was low In group B (P <0.05). Conclusion Morphine sulfate sustained-release tablets combined with radiotherapy in the treatment of moderate-to-severe bone metastases pain, the analgesic effect is rapid and more durable, improve the quality of life of patients.