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通过诱导急性白血病肿瘤细胞自分泌白细胞介素６和肿瘤坏死因子，利用急性白血病原代肿瘤细胞和肿瘤细胞系ＨＬ－６０和Ｋ５６２，分别观察了ＩＬ－６和ＴＮＦα对急性白血病细胞的调控作用。结果发现，急性白血病细胞存在着ＩＬ－６和ＴＮＦα的自分泌作用，而ＴＮＦα和ＩＬ－６对白血病细胞则有诱导分化作用；进一步研究发现，ＴＮＦα对急性白血病细胞株还可呈现生长抑制作用；而ＩＬ－６则可表现为生长促进作用。ＩＬ－６和ＴＮＦα对急性白血病细胞的这种凋控在白血病的发病和免疫调控治疗中将有意义。
Through the induction of autologous interleukin-6 and tumor necrosis factor in acute leukemia tumor cells and the use of acute leukemia primary tumor cells and tumor cell lines HL-60 and K562, the regulatory effects of IL-6 and TNFα on acute leukemia cells were observed. The results showed that IL-6 and TNFα autocrine activity existed in acute leukemia cells, while TNFα and IL-6 induced differentiation of leukemia cells. Further studies found that TNFα could also inhibit the growth of acute leukemia cell lines. IL-6 can be expressed as a growth promoting effect. This letdown of IL-6 and TNF[alpha] in acute leukemia cells will be of interest in the pathogenesis of leukemia and immunomodulatory therapy.