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为探讨心钠素（ANP）对急性肾功能衰竭的治疗作用，用阻断肾动脉建立了实验性兔缺血性急性功能衰竭模型，并应用ANP治疗。治疗结果表明：与对照组相比较，肾小球滤过率6.02±0．75VS2.05±1．05ml／min，尿量381.67±217.75VS23.20±9．35μl／min，P值均＜0001。提示心钠素可有效改善急性肾功能衰竭的肾功能。
To investigate the therapeutic effect of atrial natriuretic peptide (ANP) on acute renal failure, an experimental rabbit model of acute ischemic acute ischemia was established by blocking renal artery and treated with ANP. The treatment results showed that compared with the control group, glomerular filtration rate 6.02 ± 0.75VS2.05 ± 1.05ml / min, urine output 381.67 ± 217.75VS23.20 ± 9.35μl / min, all P <0001 . Atrial natriuretic peptide can effectively improve the renal function of acute renal failure.