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国际上,肺动脉高压(Pulmonary arterial hypertension,PAH)被定义为患者静息时平均肺动脉压力≥25 mm Hg(1 mm Hg=0.133 k Pa),而肺毛细血管楔压<15 mm Hg,肺血管阻力指数>3 Wood单位·平方米[1-3]。PAH可见于多种儿科疾病,如先天性心脏病、慢性肺疾病、血液病等,是患儿重要的致死原因之一[4]。先天性心脏病患儿常并存有显著增加的肺血流、肺静脉阻塞、紫绀等,因此在术后最易进展为PAH[5]。由于手术治疗先天性心脏病本身要引起暂
Internationally, Pulmonary arterial hypertension (PAH) is defined as the mean pulmonary artery pressure at rest at ≥25 mm Hg (1 mm Hg = 0.133 k Pa), while pulmonary capillary wedge pressure <15 mm Hg, pulmonary vascular resistance Index> 3 Wood Units [sqm] [1-3]. PAH can be seen in a variety of pediatric diseases, such as congenital heart disease, chronic lung disease, blood disease, is one of the important causes of death in children [4]. Children with congenital heart disease often coexist with significantly increased pulmonary blood flow, pulmonary vein occlusion, cyanosis, etc., so the most likely postoperative progression to PAH [5]. Due to surgical treatment of congenital heart disease itself to cause temporary