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目的:分析肝胆疾病患者输血治疗前不规则抗体筛查阳性结果的分布特点及其特异性。方法:回顾性分析2013-05-01-2014-12-31检测的17 189例肝胆疾病患者不规则抗体筛查及筛查阳性的抗体鉴定结果。结果:在52例(0.30%)不规则抗体筛查阳性肝胆疾病患者中,男14例(0.12%),女38例(0.66%),女性明显高于男性(χ~2=36.413,P<0.01);其中Rh系统有24例(46.15%),血清学表型主要以CCDee(23.08%)为主;MNS系统有18例(34.62%),血清学表型主要以NN(34.62%)为主;在肝胆专科疾病分类中主要以原发性、转移性肝癌(51.92%)为主,其次为肝内外胆管结石、胆囊结石(30.77%)。结论:不规则抗体的筛查可以有效预防和减少肝胆疾病患者输血不良反应的发生,确保临床输血更加安全、有效。
Objective: To analyze the distribution characteristics and specificity of positive results of irregular antibody screening before transfusion in patients with hepatobiliary disease. Methods: A retrospective analysis of 17 189 samples of hepatobiliary diseases from 2013-05-01-2014-12-31 was used to screen for irregular antibodies and positive results of antibody screening. Results: In 52 cases (0.30%) of irregular antibodies screening for positive hepatobiliary diseases, there were 14 males (0.12%) and 38 females (0.66%) with significantly higher females than females (χ ~ 2 = 36.413, P < 0.01). Rh system was found in 24 cases (46.15%), serological phenotype was mainly CCDee (23.08%), MNS system was in 18 cases (34.62%), serological phenotype was NN The main diseases were hepatocellular and hepatocellular carcinoma (51.92%), followed by extrahepatic bile duct stones and gallstone (30.77%). Conclusion: The screening of irregular antibodies can effectively prevent and reduce the incidence of transfusion adverse reactions in patients with hepatobiliary diseases and ensure the safety and effectiveness of clinical transfusion.