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本文报导系将具有祛风湿和刺激皮肤及神经末梢反射、扩散血管、促进新陈代谢和止痛作用的挥发性药物—冬青油、松节油、樟脑及薄荷脑等成功的制成了微型胶囊,不仅可避免上述药物在制剂中的挥发损失,而且还可将微囊作为固体成分加入到其它制剂中使用,既可简化制剂的操作手续又可延缓药效。作者应用此种微囊制备“药用热敷袋”已初获成效。临床应用“热敷袋”治疗风湿性关节炎、腰腿痛及寒性胃痛和腹痛等疾病已有悠久的历史,出于作用明显使用方便故深受患者的欢迎。但“热敷袋”这一物理疗法仅能使疼痛得到暂时的缓解,在此基础上如能同时配合药物治疗则可能会得到更好的治疗效果。常用于外敷治疗风湿性关节炎和腰腿痛的药物多系一些挥发性物质,于是我们便将它们研制成微型胶囊,然后再加入到市售“热敷袋”中,用时加以揉搓,微囊即破裂,并逐渐释放出药物。随着热敷袋温度的持续上升,而挥发扩散到“袋”外,并穿透皮肤而产生热敷和药物治疗的双重作用。
In this paper, we successfully made microcapsules of volatile drugs such as wintergreen oil, turpentine, camphor and menthol with the effects of rheumatism and irritation on the skin and nerve endings, diffusing blood vessels and promoting metabolism and analgesia. Drugs in the preparation of the volatile loss, but also the microcapsule can be used as a solid component added to other formulations, both to simplify the preparation of the operating procedures can delay the efficacy. The author of this microcapsule preparation “medicinal heat bag ” has achieved initial success. Clinical application “hot bag” treatment of rheumatoid arthritis, low back pain and cold stomachache and abdominal pain and other diseases has a long history, out of the obvious role of easy to use so by the patient’s welcome. However, the “hot bag” this physical therapy can only temporarily relieve pain, on the basis of such treatment can be treated with the same time may be better treatment. Drugs commonly used in topical applications for the treatment of rheumatoid arthritis and low back pain are mostly made of volatile materials and we develop them into microcapsules which are then added to the commercially available “hot packs” for rubbing with time The capsule ruptures and gradually releases the drug. As the temperature of the heat pack continues to rise, the heat diffuses into the “bag” and penetrates the skin creating the dual effects of heat and medication.