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安氟醚麻醉后血清中无机氟化物达一定浓度,就可能产生肾毒反应,一般吸4小时后血清无机氟化物浓度为22.2±2.8μM。Mazze 等报道成人的血清无机氟化物达15μM 时,最大浓度缩尿功能将降低25%,Cousins 则定成人平均使用安氟醚2.7±0.3MAC-hr,小儿随年龄增长肾功能才逐渐成熟,但血清无机氟化物对小儿的肾毒作用尚未见报道。作者选择8例健康男孩(1～9岁)在安氟醚麻醉下行耳鼻喉手术,观察研究血清无机氟化物浓度变化。术前均经直肠注入5%甲乙炔巴比妥25mg/kg 或静注硫贲妥钠4 mg/kg,面罩吸70%
Enroflurane anesthesia in serum fluoride in a certain concentration, it may have a nephrotoxic reaction, the general absorption of serum inorganic fluoride 4 hours after the concentration of 22.2 ± 2.8μM. Mazze et al reported adult serum fluoride levels up to 15μM, the maximum concentration of reduced urinary function will be reduced by 25%, Cousins is set average adult use of enrofloxacin 2.7 ± 0.3MAC-hr, children with age, renal function gradually matured, but Serum inorganic fluoride on children’s nephrotoxicity has not been reported. The author chooses 8 healthy boys (1 ~ 9 years old) under enflurane anesthesia for ENT surgery, observing the change of serum inorganic fluoride concentration. Preoperative rectal injection of 5% acetophenone barbital 25mg / kg or intravenous injection of 4% sodium thiophanate, mask suction 70%