论文部分内容阅读
目的探讨同步放化疗治疗中晚期宫颈癌的疗效。方法 86例中晚期宫颈鳞癌放疗患者随机分为同步放化疗组(n=46)、单纯放疗组(n=40),观察两组治疗效果及副反应并比较分析。结果放疗结束时两组有效率分别为100%、97.50%,差异无统计学意义(P>0.05)。两组5年生存率、局部复发率和远处转移率比较,差异有统计学意义(P<0.05)。同步放化疗组有较明显的骨髓抑制及胃肠道反应,与单纯放疗组比较差异有统计学意义(P<0.05),远期不良反应发生率两组差异无统计学意义(P>0.05)。结论同步放化疗与单纯放疗比较,能明显提高患者的5年生存率,降低患者的局部复发率和远处复发率。同步放化疗组有较明显的骨髓抑制和消化道反应,但患者经治疗后均可耐受。
Objective To investigate the efficacy of concurrent chemoradiotherapy in the treatment of advanced cervical cancer. Methods Eighty-six patients with advanced squamous cell carcinoma of the cervix undergoing radiotherapy were randomly divided into concurrent radiotherapy and chemotherapy group (n = 46) and radiotherapy alone group (n = 40). The therapeutic effects and side effects of the two groups were compared and analyzed. Results The effective rates of the two groups at the end of radiotherapy were 100% and 97.50%, respectively, with no significant difference (P> 0.05). The difference of 5-year survival rate, local recurrence rate and distant metastasis between the two groups was statistically significant (P <0.05). There was significant difference between the two groups in the incidence of long-term adverse reactions (P> 0.05). There was no significant difference between the two groups (P> 0.05) . Conclusions Simultaneous chemoradiotherapy and radiotherapy alone can significantly improve the 5-year survival rate and reduce the local recurrence rate and distant recurrence rate in patients. Synchronous radiotherapy and chemotherapy group had more obvious myelosuppression and gastrointestinal reactions, but patients can be tolerated after treatment.