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目的探讨胃癌腹腔液中层粘连蛋白含量与其病理生物学行为及腹膜转移相关因素的关系。方法术中收集50例胃癌和10例胃良性病变的腹水或腹腔冲洗液,采用放射免疫技术检测上清液中层粘连蛋白、CEA蛋白(p-CEA)含量,同时进行腹腔冲洗细胞学(peritoneal lavage cytology,PLC)和病理学检查。结果层粘连蛋白含量与胃癌组织学类型、生长方式、浸润深度及淋巴结转移呈正相关。PLC和p-CEA阳性组层粘连蛋白含量均高于阴性(P<0.05);肉眼腹膜转移的10例中层粘连蛋白均显著升高。全组层粘连蛋白含量升高者占68%,明显高于p-CEA(44%)和PLC(34%)的阳性率。结论腹腔液中的层粘连蛋白是反映胃癌生物学行为的分子标志物,与胃癌腹膜转移密切相关,其预测腹膜亚临床转移的灵敏性优于p-CEA和PLC。
Objective To investigate the relationship between the content of laminin in peritoneal fluid of gastric cancer and its pathobiological behavior and related factors of peritoneal metastasis. Methods 50 cases of gastric cancer and 10 cases of benign gastric lesion were collected during operation. The contents of laminin and CEA protein in supernatant were determined by radioimmunoassay. Peritoneal lavage cytology, PLC) and pathology. Results The laminin level was positively correlated with histological type, growth pattern, depth of invasion and lymph node metastasis. The levels of laminin in PLC and p-CEA positive group were significantly higher than those in negative group (P <0.05). The increase of laminin in the whole group accounted for 68%, which was significantly higher than that of p-CEA (44%) and PLC (34%). Conclusions Laminin in peritoneal fluid is a molecular marker that reflects the biological behavior of gastric cancer. It is closely related to peritoneal metastasis of gastric cancer. The sensitivity of peritoneal subclinical metastasis is better than that of p-CEA and PLC.