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目的：比较替普瑞酮加雷尼替丁与单用雷尼替丁治疗慢性浅表性胃炎的疗效。方法：８６例慢性浅表性胃炎，随机分为治疗组４４例，男性２７例，女性１７例，年龄４８±ｓ９ａ，用替普瑞酮５０ｍｇ，饭后ｐｏ，ｔｉｄ，雷尼替丁１５０ｍｇ，ｐｏ，ｂｉｄ；对照组４２例，男性２４例，女性１８例，年龄４７±７ａ，单用雷尼替丁１５０ｍｇ，ｐｏ，ｂｉｄ。疗程均为８ｗｋ。结果：治疗组各症状改善均优于对照组（Ｐ＜０．０１）。２组胃粘膜非活动性炎症好转率无显著性差异（Ｐ＞０．０５）。治疗组活动性炎症好转率优于对照组（Ｐ＜０．０１）。结论：替普瑞酮联合雷尼替丁治疗慢性浅表性胃炎优于单用雷尼替丁。
Objective: To compare the efficacy of teprenone plus ranitidine and ranitidine alone in the treatment of chronic superficial gastritis. Methods: Eighty-six chronic superficial gastritis were randomly divided into treatment group (n = 44), 27 males and 17 females, aged 48 ± s9a, with teprenone 50 mg, po, tid, ranitidine 150 mg, po, bid; control group of 42 patients, 24 males and 18 females, age 47 ± 7a, ranitidine alone 150mg, po, bid. Treatment are 8wk. Results: All the symptoms of the treatment group improved better than the control group (P <0.01). There was no significant difference between the two groups (P> 0.05). The rate of active inflammation improvement in the treatment group was better than that in the control group (P <0.01). Conclusion: Teprenone combined with ranitidine is superior to ranitidine in the treatment of chronic superficial gastritis.