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目的探讨急性加重期慢性肺心病患者血清尾加压素Ⅱ(Urotensin Ⅱ,UⅡ)、一氧化氮(NO)的浓度检测及其临床意义。方法以2006年11月至2007年3月佳木斯大学附属第一医院呼吸内科收治的急性加重期慢性肺心病患者55例(肺心病组)及健康体检者40名(正常对照组)为研究对象,分别检测血清UⅡ和NO浓度。所有研究对象均记录吸烟史,同时肺心病组中37例抽取动脉血进行血气分析,观察血清UⅡ、NO浓度与动脉血氧分压(PaO2)、动脉血二氧化碳分压(PaCO2)及吸烟史的相关性。结果肺心病组血清UⅡ和NO浓度均明显高于正常对照组(P均<0.01);肺心病组血清UⅡ、NO浓度与PaO2、PaCO2并无相关性。结论血清UⅡ、NO浓度在急性加重期慢性肺心病患者中明显升高,其比值失衡可能是肺心病发病机制之一。
Objective To investigate the serum concentration of urotensin Ⅱ (UⅡ) and nitric oxide (NO) in patients with chronic cor pulmonale and its clinical significance. Methods From November 2006 to March 2007, 55 patients with chronic cor pulmonale (pulmonary heart disease) and 40 healthy controls (normal control group) were enrolled in the First Affiliated Hospital of Jiamusi University. Serum U Ⅱ and NO concentrations were detected. All subjects were recorded smoking history, while pulmonary heart disease group 37 cases of arterial blood gas analysis, observed serum U Ⅱ, NO concentration and arterial partial pressure of oxygen (PaO2), arterial partial pressure of carbon dioxide (PaCO2) and smoking history Correlation. Results The concentrations of serum UⅡand NO in pulmonary heart disease group were significantly higher than those in normal control group (all P <0.01). There was no correlation between the levels of serum UⅡ and NO in pulmonary heart disease group and PaO2 and PaCO2. Conclusions Serum UⅡ and NO concentrations were significantly increased in patients with chronic pulmonary heart disease in acute exacerbation. The imbalanced ratio may be one of the pathogenesis of pulmonary heart disease.