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本文考察了氟比洛芬大鼠在体肠吸收的动力学特征。采用大鼠在体单向灌流法,利用HPLC法测定氟比洛芬的含量,研究氟比洛芬在小肠段(十二指肠、空肠、回肠)和结肠的吸收情况,并考察药物浓度和灌流速度对氟比洛芬吸收的影响。结果表明:小肠段与结肠段的药物吸收速率常数(Ka)和表观吸收系数(Papp)均无显著性差异(P>0.05);药物质量浓度在4.0、10.0和16.0 mg.L 1时,Ka均无显著差异(P>0.05);质量浓度为4.0和10.0 mg.L 1时,其Papp有显著的差异(P<0.05);质量浓度为10.0和16.0 mg.L 1时,其Papp无显著性差异(P>0.05);不同灌流速度下Ka和Papp有显著相差异(P<0.05)。以上结果说明氟比洛芬在全肠道吸收良好,无特定吸收部位;氟比洛芬在整个肠段的吸收以易化扩散为主,同时可能伴随有膜动转运机制;不同灌流速度对氟比洛芬的吸收速率常数和表观吸收系数均有显著性影响。
This article examines the kinetic profile of flurbiprofen in rats in vivo. The rats were subjected to one-way perfusion in vivo, the content of flurbiprofen was determined by HPLC, and the absorption of flurbiprofen in the small intestine (duodenum, jejunum, ileum) and colon was studied. The drug concentration and Effect of perfusion velocity on the absorption of flurbiprofen. The results showed that the drug absorption rate constant (Ka) and apparent absorption coefficient (Papp) of the small intestine and the colon were not significantly different (P> 0.05). When the drug concentration was 4.0, 10.0 and 16.0 mg.L 1, (P> 0.05). There was a significant difference in Papp between 4.0 and 10.0 mg.L 1 (P <0.05), Papp at mass concentrations of 10.0 and 16.0 mg.L 1 (P> 0.05). There was significant difference between Ka and Papp under different perfusion rates (P <0.05). The above results indicate that flurbiprofen is well absorbed in the whole intestine and has no specific absorption site. Flurbiprofen is mainly absorbed in the intestine and facilitated the membrane transport mechanism. Different perfusion rates affect fluoride The absorption rate constants and apparent absorption coefficients of bilipid have significant effects.