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本文对8项研究进行回顾性研究,讨论单用米索前列醇终止早孕的效果及存在问题。 8项中仅1项对单独口服米索前列醇与米非司酮配伍米索前列醇终止早孕的疗效进行了对比,结果前者成功率仅5％。另7项均使用阴道单独放置米索前列醇终止早孕,分述如下:①比较氨甲喋呤配伍米索前列醇与单用米索前列醇终止≤56 d妊娠的效果。后者首次剂量800 μg,未流产者24 h后重复给药,治疗开始后14 d测定成功率,结果其效果不如前者。②两种单用米索前列醇方法终止孕5～7周和孕8～11周妊娠。第1组200μg/12 h×4,第2组400 μg/12 h×4。治疗48h不全流产或阴道出血过多则手术终止。5～7周与8～11周成功率第1组分别为19％和25％,第2组分别为37％和30％。③4种不同阴道用药方法终止≤10周妊娠:200 μg/8
In this paper, we retrospectively studied 8 studies to discuss the effect and problems of termination of early pregnancy with misoprostol alone. Only one of eight items compared the efficacy of misoprostol alone with mifepristone in combination with misoprostol to terminate early pregnancy, with a success rate of only 5%. The other seven were using vaginal misoprostol placed termination of early pregnancy, are as follows: ① compare methotrexate with misoprostol and misoprostol alone ≤ 56 d pregnancy termination effect. The latter for the first dose of 800 μg, abortion were repeated 24 hours after treatment, 14 days after the start of treatment to determine the success rate, the result is not as effective as the former. ② two single misoprostol termination of pregnancy 5 to 7 weeks pregnant and 8 to 11 weeks of pregnancy. Group 1 200μg / 12 h × 4, Group 2 400 μg / 12 h × 4. 48h treatment of incomplete abortion or vaginal bleeding is too much termination of surgery. The success rates of 5-7 weeks and 8-11 weeks were 19% and 25% in group 1, and 37% and 30% in group 2, respectively. ③ 4 different methods of vaginal termination of pregnancy ≤ 10 weeks: 200 μg / 8