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近十年多来有关前列腺素的性质、生理功能及与临床医学关系的研究取得了可喜的进展,并且发现机体内许多组织细胞均可产生前列腺素。1976年Moncada等在血小板和血管内皮细胞中发现了血栓索A_2(ThromboxaneA_2,TXA_2)和前列环素(Prostacyclin,PGI_2),这两种物质在体内具有重要的生物学活性。目前有关肾性前列腺素与婴幼儿肾功能关系的报道日趋增多,而儿科使用环化加氧酶抑制剂又较为广泛,本文仅就此问题简述如下。
In the past ten years and more, researches on the prostaglandin’s properties, physiological functions and relations with clinical medicine have made gratifying progress and found that many tissue cells in the body can produce prostaglandin. In 1976, Moncada et al. Found thromboxane A_2 (TXA_2) and prostacyclin (PGI_2) in platelets and vascular endothelial cells, both of which have important biological activity in vivo. At present, the reports about the relationship between renal prostaglandin and the renal function of infants and young children are increasing, while the pediatric use of cyclooxygenase inhibitors is more extensive, this article only on the problems outlined below.