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目的研究复发性与初发性脑梗死患者的胰岛素抵抗(IR)情况。方法对42例复发性脑梗死、40例初发性脑梗死和30例对照组进行研究。测定并比较三组人群的体重指数(BMI)、平均动脉压(MAP)、糖化血红蛋白(HbA1c)、胰岛素抵抗指数(HOMA-IR)、胰岛素敏感指数(ISI)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、颈动脉内膜-中层厚度(CIMT)等指标。结果对照、初发卒中及复发卒中三组人群的HOMA-IR、ISI和CIMT存在显著的组间差异(P<0.05)。脑梗死患者的ISI与TG、LDL-C、BMI、CIMT以及MAP呈负相关,与HDL-C呈正相关。结论 IR与脑梗死复发的关系需要进一步研究证实。
Objective To study the insulin resistance (IR) in patients with recurrent and early-onset cerebral infarction. Methods 42 cases of recurrent cerebral infarction, 40 cases of primary cerebral infarction and 30 cases of control group were studied. The body mass index (BMI), mean arterial pressure (MAP), glycosylated hemoglobin (HbA1c), insulin resistance index (HOMA-IR), insulin sensitivity index (ISI), triglyceride (TG) Density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), carotid artery intima-media thickness (CIMT) and other indicators. Results There were significant differences between groups (P <0.05) in HOMA-IR, ISI and CIMT in controls, first-episode stroke and recurrent stroke. ISI in patients with cerebral infarction was negatively correlated with TG, LDL-C, BMI, CIMT and MAP, and positively correlated with HDL-C. Conclusion The relationship between IR and the recurrence of cerebral infarction needs further study to confirm.