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Dear Editor,rnThe structure of eukaryotic promoter is modular,consisting of different sub-domains(Benfey et al.,1990).Cross-talk among these sub-domains and effective combinatorial interactions between the specific cis-elementJs with respective transfactor/s usually control the strength and tissue specificity of the promoter.Further,specificity/inducibility of promoter can be modified by altering its genetic architecture through ‘cis-rearrangement’(Rushton et al.,2002)and ‘swapping of sub-domains’(Bhullar et al.,2003).