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目的:评价TCT检查、阴道镜活检和LEEP活检在宫颈上皮内瘤变(CIN)诊断中的价值,比较其差异。方法:对324例经TCT加阴道镜下活检诊断为CIN的患者进一步行LEEP,采用对比研究TCT、阴道镜下活检和IEEP活检病理结果。结果:TCT检查与阴道镜活检诊断结果的完全符合率为65.1%,TCT结果与LEEP活检病理学诊断结果的完全符合率为69.4%,诊断过度11.4%,诊断不足18.5%。阴道镜下宫颈活检结果与LEEP活检病理学诊断结果的完全符合率为68.2%,诊断过度21.9%,诊断不足9.3%,后两种方法的诊断结果差异有统计学意义(P<0.01)。结论:TCT是辅助诊断CIN的有效方法;单独阴道镜下活检诊断CIN的准确性尚不够理想,阴道镜下活检不能替代LEEP活检;TCT诊断CIN者在初次治疗时可用LEEP一次完成诊断和治疗。
Objective: To evaluate the value of TCT examination, colposcopy biopsy and LEEP biopsy in the diagnosis of cervical intraepithelial neoplasia (CIN), and to compare the differences. Methods: A total of 324 patients with CIN diagnosed by colposcopy and colposcopy biopsy underwent further LEEP. TCT, colposcopic biopsy and IEEP biopsy results were compared. Results The complete coincidence rate between TCT and colposcopy biopsy was 65.1%. The exact coincidence rate between TCT and LEEP biopsy was 69.4%, 11.4% and 18.5% respectively. The coincidence rate of colposcopy biopsy results and LEEP biopsy pathology was 68.2%, 21.9% and 9.3%, respectively. The difference between the two methods was statistically significant (P <0.01). CONCLUSION: TCT is an effective method to diagnose CIN. The accuracy of colposcopic biopsy in diagnosing CIN is not good enough. Colposcopy biopsy can not replace LEEP biopsy. The diagnosis of CIN in TCT can be diagnosed and treated with LEEP in the first treatment.