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为了阐明维生素 E 和硒缺乏与克山病病因的关系,检查了维生素 E 和硒对饲克山病病区粮动物之肝脏 T_4 5＇-脱单碘酶活性的影响。发现在饲料中加维生素 E 和硒都能使肝脏T_4 5＇-脱单碘酶活性高于病区粮组动物,并使肝脏脂质过氧化物含量明显低于病区粮组,其中维生素 E的效果好于硒。初步证明维生素 E 和硒增加肝脏T_4 5＇-脱单碘酶活性作用的机制是二者阻断肝脏脂质过氧化反应及减轻肝脏损伤的结果。
In order to elucidate the relationship between vitamin E and selenium deficiency and the etiology of Keshan disease, we examined the effect of vitamin E and selenium on the activity of T_4 5’-deaminase in liver of grain animals in the area of Keshan disease. Found in the feed plus vitamin E and selenium can make the liver T_4 5’-deaminase activity was higher than ward animals, and the liver lipid peroxidation was significantly lower than ward food group, including vitamin E The effect is better than selenium. Preliminary evidence that vitamin E and selenium increase liver T_4 5’-deaminase activity of the mechanism of the two are the result of blocking the liver lipid peroxidation and reduce liver damage.