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应用Ｔ细胞疫苗于同种心脏移植的研究，用ＣｏｎＡ和ＣＤ３单抗诱导受同种特异性抗原（Ｃ５７ＢＬ／６（Ｈ－２ｂ）小鼠脾细胞）免疫的ＢＡＬＢ／Ｃ（Ｈ－２ｄ）小鼠，取后者脾细胞所制备的Ｔ细胞疫苗具有延长同种心脏移植物的存活期。受Ｔ细胞疫苗接种的ＢＡＬＢ／Ｃ（Ｈ－２ｄ）鼠脾细胞对经ＣｏｎＡ激活或未激活的Ｃ５７ＢＬ／６小鼠脾细胞皆表现出特异的强烈的增殖反应，而对同系脾细胞呈低的反应。Ｔ细胞疫苗表型分析也证实：ＣｏｎＡ诱导的ＣＤ８＋克隆数大于ＣＤ３单抗。说明在接种Ｔ细胞疫苗后，所产生的抗独特型Ｔ细胞可调节宿主的抗移植排斥反应。
Using a T cell vaccine for cardiac allograft studies, BALB/C (H-2d) cells that were immunized with ConA and CD3 monoclonal antibodies that were immunized with allo-specific antigens (C57BL/6 (H-2b) mouse spleen cells) were induced In mice, the T cell vaccine prepared from the latter spleen cells has prolonged survival of allogeneic cardiac grafts. The BALB/C(H-2d) mouse spleen cells inoculated with T-cell vaccine showed a specific strong proliferative response to splenocytes of ConA-activated or non-activated C57BL/6 mice, and was low for syngeneic spleen cells. reaction. Phenotypic analysis of T cell vaccines also confirmed that ConA-induced CD8+ clones were greater than CD3 mAbs. It shows that the anti-idiotypic T cells produced after vaccination with T cell vaccine can regulate the host’s anti-graft rejection.