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目的探讨阿托伐他汀对颈动脉粥样斑块的临床影响。方法选择80例经颅多普勒超声检查发现存在颈动脉粥样斑块的患者,口服阿托伐他汀10mg,每晚1次,疗程6个月。治疗前及治疗后3个月、6个月分别检查颈动脉粥样斑块的面积及内膜中层厚度(IMT),观察其变化。结果阿托伐他汀治疗6个月后,颈动脉粥样斑块缩小、内膜中层厚度减轻、LDL-C、TG降低,HDL升高(P<0.05)。结论阿托伐他汀具有降血脂及稳定与消退颈动脉粥样斑块的作用。
Objective To investigate the clinical effect of atorvastatin on carotid artery plaque. Methods Eighty patients with carotid atherosclerotic plaques were examined by transcranial Doppler ultrasonography. Oral atorvastatin 10 mg was given once a night for 6 months. Carotid plaque area and intima-media thickness (IMT) were examined before treatment, 3 months and 6 months after treatment, and the changes were observed. Results Atorvastatin 6 months later, carotid artery atherosclerotic plaque was reduced, intima-media thickness was reduced, LDL-C, TG decreased, HDL increased (P <0.05). Conclusions Atorvastatin has the effect of lowering blood fat, stabilizing and eliminating carotid artery plaque.