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目的探讨急性白血病 (AL)患者纤溶系统的异常。方法发色底物法和 EL ISA法测定 93例患者血浆一系列纤溶指标。结果患者血浆组织纤溶酶原激活物活性、D-二聚体 (D- D)水平显著升高 ;纤溶酶原活性 (PL G)、α2 抗纤溶酶活性 (α2 - PI)、纤溶酶原激活抑制物活性 (PAI)水平降低 ;缓解后均恢复正常。结论 AL 患者存在纤溶系统的激活 ,部分指标与 AL 分型、出血程度和预后有关
Objective To investigate the abnormal fibrinolytic system in patients with acute leukemia (AL). Methods A series of fibrinolytic indexes of 93 patients were determined by chromogenic substrate method and EL ISA method. Results The activity of plasminogen activator and the level of D-dimer (D-D) in plasma were significantly increased. The activities of plasminogen activator (PL G), α2 antiplasmin (α2 - Reduced activity of plasminogen activator inhibitor (PAI); all returned to normal after remission. Conclusion The activation of fibrinolytic system exists in AL patients. Some indicators are related to the type of AL, the degree of bleeding and the prognosis