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目的 观察急性心肌梗塞患者应用吲达帕胺对左室收缩及舒张功能的影响 ,及其在预防左室重构中的作用。方法 急性心肌梗塞患者 6 6例 ,随机分为吲达帕胺治疗组 (31例 )和对照组 (35例 )。用脉冲多普勒超声心动图测定等容舒张时间 (IVRT)、二尖瓣口血流频谱、肺静脉血流频谱和左室射血分数。结果 吲达帕胺治疗组的IVRT、EDT和AR波时间明显缩短 ,E/A比值、S/D比值和EF明显升高 ,AR波幅明显降低 (P <0 0 1)。结论吲达帕胺能显著改善急性心肌梗塞患者的左室收缩及舒张功能 ,提示吲达帕胺能预防左室重构。
Objective To observe the effect of indapamide on left ventricular systolic and diastolic function in patients with acute myocardial infarction and its role in preventing left ventricular remodeling. Methods Sixty-six patients with acute myocardial infarction were randomly divided into indapamide group (n = 31) and control group (n = 35). Pulse-Doppler echocardiography was used to determine isovolumetric relaxation time (IVRT), mitral valve flow spectrum, pulmonary venous flow and left ventricular ejection fraction. Results The IVRT, EDT and AR wave time of indapamide group were significantly shortened, and the E / A ratio, S / D ratio and EF were significantly increased and AR amplitude was significantly decreased (P <0.01). Conclusion Indapamide can significantly improve left ventricular systolic and diastolic function in patients with acute myocardial infarction, suggesting that indapamide can prevent left ventricular remodeling.