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促甲状腺素释放激素(TRH)的中枢作用有使自发运动增多,抑制摄食行为,降低体温,抑制睡眠,兴奋脊髓运动神经元等。基于TRH 的中枢作用,试验对脊髓小脑变性症运动失调、轻度迁延性意识障碍、肌肉萎缩性侧索硬化症、脊髓损伤、植物神经功能障碍、抑郁病、痴呆、癫痫、非随意性运动症等进行了治疗。其中已证实有效并应用于临床的有脊髓小脑变性症运动失调和轻度迁延性意识障碍,其余为临床试用研究阶段。
The central role of thyrotropin-releasing hormone (TRH) is to increase spontaneous movement, inhibition of feeding behavior, lower body temperature, sleep inhibition, excitement of spinal motoneurons and so on. Based on the central role of TRH, tests were performed on spinocerebellar degeneration dyskinesia, mild persistent disturbance of consciousness, amyotrophic lateral sclerosis, spinal cord injury, autonomic dysfunction, depression, dementia, epilepsy, involuntary movement disorders For treatment. Which has proven effective and clinical application of spinocerebellar degeneration dyskinesia and mild persistent disturbance of consciousness, and the rest for the clinical trial phase.