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肝损伤是指各种致病因素(物理、化学和生物性因素)作用于肝组织而引起的肝细胞的变性、坏死及肝功能的改变,多种炎性介质及细胞因子参与了肝损伤的过程。环氧化酶-2(COX-2)为一种诱导酶,当细胞受到炎症等刺激时可高表达,是炎症介导的细胞毒性重要的决定因素之一。在各种原因所导致的肝损伤中,COX-2表达增多的现象提示COX-2在肝损伤发生发展中具有重要作用,COX-2作为肝损伤的治疗靶点将成为今后研究的热点。
Liver injury refers to a variety of pathogenic factors (physical, chemical and biological factors) on the liver tissue caused by degeneration, necrosis and liver function changes, a variety of inflammatory mediators and cytokines involved in liver injury process. Cyclooxygenase-2 (COX-2) is an inducible enzyme that is highly expressed when cells are stimulated by inflammation and is one of the important determinants of inflammation-mediated cytotoxicity. The increased expression of COX-2 in liver injury caused by various causes suggests that COX-2 plays an important role in the development of liver injury. COX-2, as a therapeutic target of liver injury, will become a hot topic in the future.