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[目的]通过与西药作用对比,观察中药桃核承气改良方对兔血管损伤后内皮细胞生长及功能的影响。[方法]40只兔随机数字表法分为四组,模型组(n=11)、中药组(n=12)、西药组(n=11)和空白组(n=6)。造模后模型组、中药组、西药组正常饲料喂养,中药组予桃核承气改良方,西药组予舒降之、阿司匹林混合液,模型组、空白组予生理盐水各灌胃4周。[结果]32只白兔进入结果分析,模型组(n=8)、中药组(n=10)、西药组(n=8)和空白组(n=6)。①与空白组相比,其他三组造模后1d血清一氧化氮含量下降(P<0.05)。造模后28d兔中药组、西药组较模型组NO明显升高(P<0.05)。②模型组VEGF表达明显高于其他3组(P<0.05)。[结论]桃核承气改良方能够促进血管内皮细胞的修复,防治再狭窄。
[Objective] To compare the effects of the traditional Chinese medicine Taohe Chengqi reform prescription on the growth and function of endothelial cells after rabbit vascular injury. [Methods] Forty rabbits were randomly divided into four groups: model group (n=11), Chinese medicine group (n=12), western medicine group (n=11) and blank group (n=6). After modeling, the model group, Chinese medicine group, and western medicine group were fed normally, the Chinese medicine group was treated with Taohe Chengqi improvement group, the western medicine group was administered with Shujiangzhi and aspirin mixture, and the model group and blank group were administered saline for 4 weeks. [Results] Thirty-two white rabbits were involved in the analysis of results, model group (n=8), Chinese medicine group (n=10), western medicine group (n=8) and blank group (n=6). 1Compared with the blank group, serum nitric oxide levels in the other three groups decreased 1 d after modeling (P<0.05). At 28 days after modeling, NO was significantly higher in the Chinese herb and western medicine groups than in the model group (P<0.05). 2 The expression of VEGF in the model group was significantly higher than that in the other 3 groups (P<0.05). [Conclusion] Taohe Chengqi modified prescription can promote the repair of vascular endothelial cells and prevent restenosis.