论文部分内容阅读
1目的 探讨慢性支气管炎病人血清肿瘤坏死因子 - α(TNF- α)水平变化及其与病情的关系。 2方法应用 EL ISA法测定 42例慢性支气管炎病人血清 TNF- α水平 ,并与 40例正常人进行了比较。 3结果 慢性支气管炎急性发作期病人 TNF- α水平明显高于对照组 (F=12 6 .49,q=118.5 5 ,P<0 .0 1) ;并发呼吸衰竭病人 TNF- α水平明显高于未并发呼吸衰竭者 (q=32 .19,P<0 .0 1) ;临床缓解期病人 TNF- α水平明显低于急性发作期病人 (q=2 2 .36 ,P<0 .0 1)。 4结论 血清 TNF- α含量测定可作为评估慢性支气管炎病人病情轻重程度及判断预后的参考指标之一
1 Objective To investigate the changes of serum tumor necrosis factor-α (TNF-α) levels in patients with chronic bronchitis and its relationship with the disease. 2 Methods Serum levels of TNF-α in 42 patients with chronic bronchitis were measured by EL-ISA and compared with 40 healthy controls. 3 Results Patients with chronic bronchitis acute exacerbation of TNF-α levels were significantly higher than the control group (F = 12 6.49, q = 118.5 5, P <0.01); patients with respiratory failure TNF-α levels were significantly higher The level of TNF-α in patients with clinical remission was significantly lower than that in patients with acute exacerbation (q = 32.26, P <0.01), but not in patients with respiratory failure (q = 32.19, P <0.01) . 4 Conclusion serum TNF-α levels can be used as a measure of severity of chronic bronchitis and prognosis of patients with one of the indicators