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We proposed a hybrid tilted fiber gratings (polarizing grating and tilted fiber Bragg grating)-based surface plasmon resonance (SPR) sensor.The hybrid tilted fiber grating,consisting of a polarizing grating and tilted fiber Bragg grating (TFBG),is fabricated in a single-mode fiber in series by using a UV-inscription technique,in which the TFBG could generate a dense cladding mode resonance to excite SPR and the polarizing grating could filter out the S-polarization cladding mode of the TFBG.Such proposed hybrid tilted fiber gratings could greatly simplify the interrogation system of the TFBG-based SPR sensor.The experiment results showed that the hybrid tilted fiber gratings-based SPR sensor has the refractive index sensitivity of 522.8 nm/RIU.Finally,by using the proposed sensor,we have achieved the hemoglobin concentration detection within a sensing range from 0.1 mg/mL to 1.0 mg/mL and the sensitivity of 8.144 nm/(mg/mL).